Peptide Database

Peptide NameScorpion K+ toxin ImKTx1

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel inhibition ▸ Potassium channel inhibition

Venom / Toxin ▸ Neurotoxin ▸ Scorpion neurotoxin

Standard StatusStandard

Sequence Length54 amino acids

Chemical Formula-

DescriptionStandard

        MNFWVTFIRLIVVLSIVFAFQIAVAKAACVTHEDCTLLCYDTIGTCVDGKCKCM
    

Molecular Weight6006.22 Da

Isoelectric Point (pI)6.67

Net Charge (pH 7.0)-0.28

GRAVY Index1.08

Boman Index0.00

Instability Index18.11

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_178079 VERIFIED: YES

Provenance & Taxonomy

OrganismIsometrus maculatus [Animal]

FamilyScorpion potassium channel toxin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Ion channel modulation Potassium channel inhibitor Scorpion toxin Membrane-active peptide

TargetKv1.3 potassium channel

Activity10-100 nM

MethodPatch-clamp electrophysiology