MYP_178075
Czon1107
Membrane / Ion-channel modulation
▸
Ion channel inhibition
▸
Acetylcholine receptor inhibition
Venom / Toxin
Venom / Toxin
▸
Conotoxin
Standard
10 amino acids
-
Standard
GFRSPCPPFC
1110.31 Da
8.16
0.87
0.01
0.00
147.12
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0433575
VERIFIED: YES
Provenance & Taxonomy
Conus zonatus [Animal]
Single-disulfide conopeptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
6-10
Bio-Activity Profile
Ion channel modulation
Nicotinic acetylcholine receptor inhibitor
Neurotoxin
Conotoxin
Human α7 nicotinic acetylcholine receptor (SH-SY5Y cells)
77.2 ± 0.05 μM
IC50
RECORD: Rec_0433576
VERIFIED: YES
Provenance & Taxonomy
Conus zonatus [Animal]
Single-disulfide conopeptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
6-10
Bio-Activity Profile
Ion channel modulation
Nicotinic acetylcholine receptor inhibitor
Neurotoxin
Conotoxin
Human α3β4 nicotinic acetylcholine receptor (SH-SY5Y cells)
15.7 ± 3.0 μM
IC50
RECORD: Rec_178075
VERIFIED: YES
Provenance & Taxonomy
Conus zonatus [Animal]
Single-disulfide conopeptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
6-10
Bio-Activity Profile
Ion channel modulation
Nicotinic acetylcholine receptor inhibitor
Neurotoxin
Conotoxin
LC-MS/MS; NMR