Peptide Database

Peptide NameFirst-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G

Function Ontology

Antiviral

Standard StatusStandard

Sequence Length203 amino acids

Chemical FormulaC1054H1174N294O100S12

DescriptionPDB structure; X-ray @1.38Å

        GPLGSPEFELGTTEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLNQRRGFLANQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQ
    

Molecular Weight23602.39 Da

Isoelectric Point (pI)6.04

Net Charge (pH 7.0)-4.57

Net Charge (pH 7.4) -5.77

Charge Density (pH 7.0) -0.0225

GRAVY Index-0.54

Hydrophobic Moment 0.09

Boman Index-0.05

Instability Index40.33

Aliphatic Index 65.37

Aromaticity 0.1724

Extinction Coeff. Reduced 40450.00

Extinction Coeff. Oxidized 40950.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7997.91

LogP 28.46

H-bond Donors 158.0

H-bond Acceptors 320.0

Rotatable Bonds 407.0

Heavy Atoms 1483.0

Ring Count 51.0

Amide Bonds 399.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0431350 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [other]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral

MethodX-ray