Peptide Database

Peptide NameFirst-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G

Function Ontology

Antiviral

Standard StatusStandard

Sequence Length207 amino acids

Chemical FormulaC1072H1193N301O105S11

DescriptionPDB structure; X-ray @2.04Å

        GPLGSPEFELGTTEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLNQRRGFLANQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYDDQGRAQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQEN
    

Molecular Weight24055.77 Da

Isoelectric Point (pI)5.89

Net Charge (pH 7.0)-5.50

Net Charge (pH 7.4) -6.62

Charge Density (pH 7.0) -0.0266

GRAVY Index-0.60

Hydrophobic Moment 0.09

Boman Index-0.06

Instability Index40.68

Aliphatic Index 64.59

Aromaticity 0.1691

Extinction Coeff. Reduced 40450.00

Extinction Coeff. Oxidized 40825.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8245.72

LogP 22.96

H-bond Donors 161.0

H-bond Acceptors 327.0

Rotatable Bonds 416.0

Heavy Atoms 1512.0

Ring Count 51.0

Amide Bonds 410.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0431349 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [other]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral

MethodX-ray