Peptide Database

Peptide NameStructure based design of RIP1 kinase inhibitors

Function Ontology

Cell-penetrating

Standard StatusStandard

Sequence Length297 amino acids

Chemical FormulaC1497H1777N395O145S18

DescriptionPDB structure; X-ray @2.52Å

        GGSGQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE
    

Molecular Weight33551.39 Da

Isoelectric Point (pI)5.58

Net Charge (pH 7.0)-7.33

Net Charge (pH 7.4) -8.10

Charge Density (pH 7.0) -0.0247

GRAVY Index-0.29

Hydrophobic Moment 0.11

Boman Index0.03

Instability Index47.96

Aliphatic Index 89.97

Aromaticity 0.1077

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 31525.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 11106.03

LogP -32.63

H-bond Donors 193.0

H-bond Acceptors 461.0

Rotatable Bonds 616.0

Heavy Atoms 2089.0

Ring Count 48.0

Amide Bonds 581.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0431340 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [other]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-penetrating

MethodX-ray