Peptide Database

Peptide NameCrystal structure of MCL-1 in complex with a neutralizing Alphabody CMPX-383B

Function Ontology

Cell-penetrating

Standard StatusStandard

Sequence Length143 amino acids

Chemical FormulaC647H786N184O64S6

DescriptionPDB structure; X-ray @2.3Å

        GSHMSTEQIQKRTAAIQKRIAAIQKRIYAMTASGGAGAAGAGAGMSIEEITKQIAAIQLRIVGDQVQIAYQTASGAGAGAGGMSTEEIQKQIAAIETQICKIEAAIELKEAGITSDFYFELINKAKTCEGVEALKEHILAAHT
    

Molecular Weight14932.93 Da

Isoelectric Point (pI)6.35

Net Charge (pH 7.0)-0.83

Net Charge (pH 7.4) -1.18

Charge Density (pH 7.0) -0.0058

GRAVY Index0.01

Hydrophobic Moment 0.04

Boman Index0.11

Instability Index54.81

Aliphatic Index 93.15

Aromaticity 0.0559

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5188.51

LogP 12.51

H-bond Donors 91.0

H-bond Acceptors 215.0

Rotatable Bonds 266.0

Heavy Atoms 916.0

Ring Count 8.0

Amide Bonds 283.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0431325 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [other]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-penetrating

MethodX-ray