Peptide Database

Peptide NameCrystal structure of MCL-1 in complex with a neutralizing Alphabody CMPX-383B

Function Ontology

Cell-penetrating

Standard StatusStandard

Sequence Length162 amino acids

Chemical FormulaC804H963N237O81S5

DescriptionPDB structure; X-ray @2.3Å

        GSHMGSDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
    

Molecular Weight18321.59 Da

Isoelectric Point (pI)8.63

Net Charge (pH 7.0)1.41

Net Charge (pH 7.4) 1.04

Charge Density (pH 7.0) 0.0087

GRAVY Index-0.45

Hydrophobic Moment 0.14

Boman Index-0.09

Instability Index36.05

Aliphatic Index 83.58

Aromaticity 0.1049

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6548.18

LogP 15.97

H-bond Donors 134.0

H-bond Acceptors 254.0

Rotatable Bonds 339.0

Heavy Atoms 1144.0

Ring Count 22.0

Amide Bonds 316.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0431324 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [other]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-penetrating

MethodX-ray