Peptide Database

Peptide NameCryo-EM structure of neuropeptide FF receptor 2 in the ligand-free state with BRIL fusion, anti-BRIL Fab, and nanobody

Function Ontology

Neurological / Signaling

Standard StatusStandard

Sequence Length131 amino acids

Chemical FormulaC629H686N186O69S4

DescriptionPDB structure; EM @2.91Å

        GSQVQLQESGGGLVQPGGSLRLSCAASGRTISRYAMSWFRQAPGKEREFVAVARRSGDGAFYADSVQGRFTVSRDDAKNTVYLQMNSLKPEDTAVYYCAIDSDTFYSGSYDYWGQGTQVTVSSLEHHHHHH
    

Molecular Weight14443.64 Da

Isoelectric Point (pI)6.68

Net Charge (pH 7.0)-0.58

Net Charge (pH 7.4) -1.07

Charge Density (pH 7.0) -0.0044

GRAVY Index-0.58

Hydrophobic Moment 0.12

Boman Index-0.05

Instability Index51.00

Aliphatic Index 57.33

Aromaticity 0.1603

Extinction Coeff. Reduced 22920.00

Extinction Coeff. Oxidized 23045.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5242.73

LogP 3.01

H-bond Donors 110.0

H-bond Acceptors 209.0

Rotatable Bonds 241.0

Heavy Atoms 905.0

Ring Count 26.0

Amide Bonds 255.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0431253 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [other]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Neurological / Signaling

MethodEM