Peptide Database

Peptide NameAntithrombin-III

Function Ontology

Enzyme / Catalytic activity ▸ Protease

Enzyme modulation ▸ Enzyme inhibition ▸ Blood coagulation cascade inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitor

Hemostasis

Standard StatusStandard

Sequence Length464 amino acids

Chemical FormulaC2355H2790N622O235S21

DescriptionStandard

        MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
    

Molecular Weight52601.83 Da

Isoelectric Point (pI)6.29

Net Charge (pH 7.0)-1.99

Net Charge (pH 7.4) -2.97

Charge Density (pH 7.0) -0.0043

GRAVY Index-0.28

Hydrophobic Moment 0.11

Boman Index-0.01

Instability Index39.48

Aliphatic Index 84.68

Aromaticity 0.1056

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 45880.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 17643.95

LogP -142.33

H-bond Donors 319.0

H-bond Acceptors 723.0

Rotatable Bonds 956.0

Heavy Atoms 3276.0

Ring Count 75.0

Amide Bonds 921.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0430907 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [other]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Enzyme inhibitory Protease inhibitor Enzyme inhibitory Serine protease inhibitor Hemostasis Hemostasis Blood coagulation