Peptide Database

Peptide NameGasdermin-D

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Immunology ▸ Innate immunity

Standard StatusStandard

Sequence Length484 amino acids

Chemical FormulaC2333H2739N641O234S18

DescriptionStandard

        MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH
    

Molecular Weight52800.42 Da

Isoelectric Point (pI)4.78

Net Charge (pH 7.0)-21.40

Net Charge (pH 7.4) -22.82

Charge Density (pH 7.0) -0.0442

GRAVY Index-0.17

Hydrophobic Moment 0.07

Boman Index0.05

Instability Index48.76

Aliphatic Index 93.06

Aromaticity 0.0826

Extinction Coeff. Reduced 54430.00

Extinction Coeff. Oxidized 54930.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 17978.12

LogP -173.21

H-bond Donors 332.0

H-bond Acceptors 726.0

Rotatable Bonds 958.0

Heavy Atoms 3299.0

Ring Count 78.0

Amide Bonds 932.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0430818 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [other]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Anti-inflammatory Immunomodulatory Innate immunity