Peptide Database

Peptide Namepml-RARalpha fusion protein promyelocytic leukemia antigenic peptide

Function Ontology

Anticancer ▸ Cancer antigenic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC99H110N30O19

DescriptionStandard

        NSNHVASGAGEAAIETQSSSSEEIV
    

Molecular Weight2474.50 Da

Isoelectric Point (pI)3.79

Net Charge (pH 7.0)-3.90

Net Charge (pH 7.4) -3.96

Charge Density (pH 7.0) -0.1562

GRAVY Index-0.38

Hydrophobic Moment 0.17

Boman Index0.06

Instability Index83.49

Aliphatic Index 70.40

Aromaticity 0.0400

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1017.10

LogP -5.06

H-bond Donors 19.0

H-bond Acceptors 41.0

Rotatable Bonds 39.0

Heavy Atoms 151.0

Ring Count 1.0

Amide Bonds 49.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0430644 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cancer antigenic

Targetpeptide / promyelocytic leukemia

MethodT cell recognition assay

PaperGambacorti-Passerini C, Grignani F, Arienti F, Pandolfi PP, Pelicci PG, Parmiani G. Human CD4 lymphocytes specifically recognize a peptide representing the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells. Blood. 1993 Mar 1, 81(5):1369-75. (PMID: 809516 PMID8095167 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8095167/