Peptide Database

Peptide Namedek-can fusion protein myeloid leukemia antigenic peptide

Function Ontology

Anticancer ▸ Cancer antigenic

Anticancer ▸ Cancer antigenic ▸ myeloid leukemia

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC90H123N29O7S2

DescriptionStandard

        TMKQICKKEIRRLHQY
    

Molecular Weight2075.50 Da

Isoelectric Point (pI)10.48

Net Charge (pH 7.0)4.03

Net Charge (pH 7.4) 3.89

Charge Density (pH 7.0) 0.2517

GRAVY Index-1.20

Hydrophobic Moment 0.54

Boman Index-0.47

Instability Index67.28

Aliphatic Index 73.12

Aromaticity 0.1250

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 762.45

LogP 2.63

H-bond Donors 18.0

H-bond Acceptors 30.0

Rotatable Bonds 45.0

Heavy Atoms 129.0

Ring Count 2.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0430642 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cancer antigenic

Targetpeptide / myeloid leukemia

MethodT cell recognition assay

PaperMakita M, Azuma T, Hamaguchi H, Niiya H, Kojima K, Fujita S, Tanimoto M, Harada M, Yasukawa M. Leukemia-associated fusion proteins, dek-can and bcr-abl, represent immunogenic HLA-DR-restricted epitopes recognized by fusion peptide-specific CD4+ T lymphocytes. Leukemia. 2002 Dec, 16(12):2400-7. (PMID PMID12454745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12454745/