Peptide Database

Peptide NameBCR-ABL fusion protein (b3a2) chronic myeloid leukemia antigenic peptide

Function Ontology

Anticancer ▸ Cancer antigenic

Anticancer ▸ Cancer antigenic ▸ chronic myeloid leukemia

Anticancer ▸ Cancer antigenic ▸ myeloid leukemia

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC77H96N24O7

DescriptionStandard

        ATGFKQSSKALQRPVAS
    

Molecular Weight1776.00 Da

Isoelectric Point (pI)11.69

Net Charge (pH 7.0)3.00

Net Charge (pH 7.4) 2.99

Charge Density (pH 7.0) 0.1763

GRAVY Index-0.48

Hydrophobic Moment 0.47

Boman Index-0.12

Instability Index88.49

Aliphatic Index 57.65

Aromaticity 0.0588

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 678.11

LogP -1.75

H-bond Donors 14.0

H-bond Acceptors 27.0

Rotatable Bonds 31.0

Heavy Atoms 111.0

Ring Count 2.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0430640 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cancer antigenic

Targetpeptide / chronic myeloid leukemia

MethodT cell recognition assay

PaperBosch GJ, Joosten AM, Kessler JH, Melief CJ, Leeksma OC. Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide. Blood. 1996 Nov 1, 88(9):3522-7. (PMID: 8896419) PMID8896419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8896419/