Peptide Database

Peptide NamePTPRK melanoma antigenic peptide

Function Ontology

Anticancer ▸ Cancer antigenic

Anticancer ▸ melanoma

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC90H96N20O8

DescriptionStandard

        PYYFAAELPPRNLPEP
    

Molecular Weight1874.10 Da

Isoelectric Point (pI)4.26

Net Charge (pH 7.0)-1.00

Net Charge (pH 7.4) -1.01

Charge Density (pH 7.0) -0.0625

GRAVY Index-0.72

Hydrophobic Moment 0.25

Boman Index0.06

Instability Index79.10

Aliphatic Index 61.25

Aromaticity 0.1875

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 574.03

LogP 4.32

H-bond Donors 10.0

H-bond Acceptors 23.0

Rotatable Bonds 27.0

Heavy Atoms 123.0

Ring Count 8.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0430639 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cancer antigenic

Targetautologous tumor cells / melanoma

MethodT cell recognition assay

PaperNovellino L, Renkvist N, Rini F, Mazzocchi A, Rivoltini L, Greco A, Deho P, Squarcina P, Robbins PF, Parmiani G, Castelli C. Identification of a mutated receptor-like protein tyrosine phosphatase kappa as a novel, class II HLA-restricted melanoma antigen. J Immunol. 2003 Jun 15, 170(12):6363-70. (PM PMID12794170 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12794170/