MYP_174359
PKF273-791
Binding / Molecular interaction
▸
Protein-protein interaction
not Standard
6 amino acids
-
X1 = L-thialysine (PDB SLZ); Y2 = O-phosphotyrosine (PDB PTR); N-alpha-acetyl cap excluded from residue count; side-chain lactam cyclization from Pro6 carbonyl to thialysine1 NZ.
XYVNVP
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0427672
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain lactam-cyclized peptide [Cyclic]
L-amino-acid peptide containing L-thialysine [L]
Acetylation
Intramolecular lactam: Pro6 carbonyl to L-thialysine1 side-chain NZ
X1 = L-thialysine (SLZ); Y2 = O-phosphotyrosine (PTR); N-alpha-acetylation; Pro6 carbonyl linked to thialysine1 side-chain NZ.
Bio-Activity Profile
Protein-binding
Peptide-protein interaction
Structural binding
GRB2 SH2-domain binding
growth factor receptor-bound protein 2 (GRB2) SH2 domain
X-ray crystallography