Peptide Database

Peptide NamePKF273-791

Function Ontology

Venom / Toxin ▸ General toxin ▸ Microcystin analogue

Venom / Toxin ▸ General toxin ▸ Toxin

Standard Statusnot Standard

Sequence Length13 amino acids

Chemical FormulaC54H68N16O6S1

DescriptionNon-standard

        ACESLZPTRVNVP
    

Molecular Weight0.00 Da

Isoelectric Point (pI)6.21

Net Charge (pH 7.0)-0.06

Net Charge (pH 7.4) -0.15

Charge Density (pH 7.0) -0.0048

GRAVY Index0.02

Hydrophobic Moment 0.09

Boman Index0.01

Instability Index93.93

Aliphatic Index 82.31

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0427672 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitynoncanonical or modified amino-acid cyclic peptide [Modified]

N-TermN-alpha-acetyl-L-thialysine

C-TermNone

Other ModsN-alpha-acetyl-L-thialysine; O-phosphotyrosine; CyclicPepedia normalized code ACESLZPTRVNVP maps to ligand PKF273-791

Bio-Activity Profile

Function

Protein-binding Peptide-protein interaction Structural binding GRB2 SH2-domain binding

Targetgrowth factor receptor-bound protein 2 (GRB2) SH2 domain

MethodX-ray protein-peptide complex structure