Peptide Database

Peptide NameCTOP

Function Ontology

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Standard Statusnot Standard

Sequence Length12 amino acids

Chemical Formula-

Descriptioncontains X representing unresolved or non-standard residue

        FCYWXRNTPENT
    

Molecular Weight0.00 Da

Isoelectric Point (pI)0.00

Net Charge (pH 7.0)0.00

GRAVY Index0.00

Boman Index0.00

Instability Index0.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0423176 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitymixed L/D and noncanonical amino-acid peptide [Mixed]

N-TermNone

C-TermAmidation

DisulfideCys2-Penicillamine7 disulfide bond

Other ModsD-Phe1; D-Trp4; Orn5; Pen7; C-terminal amidation; Brainpeps CTOP maps batch normalized sequence FCYWXRNTPENT to fCYwOrnTPenT-NH2

Bio-Activity Profile

Function

μ-opioid receptor antagonist Nonopioid receptor agonist

Targetunresolved nonopioid receptor in rat locus coeruleus neurons

Activity560 nM

MethodEC50 for K+ conductance increase; intracellular recording in rat locus coeruleus brain slices