Peptide Database

Peptide NameSLAY-screened peptide P453

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC73H97N23O24S

DescriptionStandard

        DLYHSYHDCHHNTA
    

Molecular Weight1712.76 Da

Isoelectric Point (pI)5.98

Net Charge (pH 7.0)-1.90

Net Charge (pH 7.4) -2.32

Charge Density (pH 7.0) -0.1358

GRAVY Index-1.38

Hydrophobic Moment 0.31

Boman Index-0.14

Instability Index61.05

Aliphatic Index 35.00

Aromaticity 0.1429

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 754.95

LogP -8.35

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 50.0

Heavy Atoms 121.0

Ring Count 6.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0302364 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/