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MYP_174000
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Basic Information
IN3(designed based on indolicidin and ranalexin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C95H135N35O14
Standard
Sequence
RRPWRWPRWPWRR
Physicochemical Analysis
1991.31 Da
12.00
5.76
5.56
0.4431
-2.72
0.71
-0.89
190.06
0.00
0.3077
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
820.71
-2.79
33.0
20.0
54.0
144.0
11.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019149 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus pneumoniae(30 clinical isolates)
62.5 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0043877 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumanii ATCC 15308
250 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0046717 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
citrobacter spp
250 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0071959 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
31.25 μg/mL
MIC
PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0097274 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human RBCs
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
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