Peptide Database

Peptide NameSLAY-screened peptide P5581

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H163N27O24S2

DescriptionStandard

        PYLLCVNRPVCFRVSAGALL
    

Molecular Weight2191.66 Da

Isoelectric Point (pI)9.06

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.85

Charge Density (pH 7.0) 0.0969

GRAVY Index1.05

Hydrophobic Moment 0.38

Boman Index0.27

Instability Index20.75

Aliphatic Index 131.50

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 800.79

LogP -5.19

H-bond Donors 31.0

H-bond Acceptors 28.0

Rotatable Bonds 66.0

Heavy Atoms 153.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0107780 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/