Peptide Database

Peptide NameSLAY-screened peptide P1656

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC86H125N19O22

DescriptionStandard

        PLWPPSIPDIFHSITG
    

Molecular Weight1777.03 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-0.95

Net Charge (pH 7.4) -1.06

Charge Density (pH 7.0) -0.0596

GRAVY Index0.21

Hydrophobic Moment 0.50

Boman Index0.40

Instability Index36.43

Aliphatic Index 97.50

Aromaticity 0.1250

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 601.92

LogP -2.80

H-bond Donors 20.0

H-bond Acceptors 22.0

Rotatable Bonds 47.0

Heavy Atoms 127.0

Ring Count 8.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0056361 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/