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MYP_173910
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Basic Information
AC-CCSP-5-Dp
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
16 amino acids
C73H127N19O18S2
Standard
Sequence
GLFAVCKKVASVCKGL
Physicochemical Analysis
1623.04 Da
9.39
2.74
2.50
0.1711
1.14
0.51
0.29
-1.24
115.62
0.0625
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
598.11
-4.49
23.0
23.0
55.0
112.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0041759 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
benzyl/aryl-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
12.1 μM
IC50
PaperShen H, Zhang N, Kong X, Wang N, Hu HG, Cong W, Liu C. Benzyl stapled modification and anticancer activity of antimicrobial peptide A4K14-Citropin 1.1. Bioorg Med Chem Lett. 2023 Nov 15;96:129499. PMID37804993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37804993/
RECORD: Rec_0099499 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
benzyl/aryl-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer Antimicrobial Antibacterial
U-87MG ATCC
9.2 μM
IC50
PaperShen H, Zhang N, Kong X, Wang N, Hu HG, Cong W, Liu C. Benzyl stapled modification and anticancer activity of antimicrobial peptide A4K14-Citropin 1.1. Bioorg Med Chem Lett. 2023 Nov 15;96:129499. PMID37804993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37804993/
RECORD: Rec_0187779 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
benzyl/aryl-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
C4-2B
35.84 μM
IC50
PaperShen H, Zhang N, Kong X, Wang N, Hu HG, Cong W, Liu C. Benzyl stapled modification and anticancer activity of antimicrobial peptide A4K14-Citropin 1.1. Bioorg Med Chem Lett. 2023 Nov 15;96:129499. PMID37804993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37804993/
RECORD: Rec_0211072 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
benzyl/aryl-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
HCT116
7.44 μM
IC50
PaperShen H, Zhang N, Kong X, Wang N, Hu HG, Cong W, Liu C. Benzyl stapled modification and anticancer activity of antimicrobial peptide A4K14-Citropin 1.1. Bioorg Med Chem Lett. 2023 Nov 15;96:129499. PMID37804993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37804993/
RECORD: Rec_0277887 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
benzyl/aryl-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
A549
16.37 μM
IC50
PaperShen H, Zhang N, Kong X, Wang N, Hu HG, Cong W, Liu C. Benzyl stapled modification and anticancer activity of antimicrobial peptide A4K14-Citropin 1.1. Bioorg Med Chem Lett. 2023 Nov 15;96:129499. PMID37804993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37804993/
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