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MYP_173888
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Basic Information
Pleurain-a1-thel
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
26 amino acids
C143H249N41O33S4
Standard
Sequence
RILTMTKRVKMPQLYKQIVCRLFKTC
Physicochemical Analysis
3199.02 Da
10.57
6.74
6.50
0.2591
-0.03
0.62
-0.15
64.24
97.31
0.0769
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1238.91
-7.90
47.0
44.0
111.0
221.0
3.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011179 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
20-26
Bio-Activity Profile
Antimicrobial Antifungal Antioxidant
including resistant strains Candida albicans 08032815
200 μg/mL
MIC
PaperA Novel Antimicrobial Peptide from Skin Secretions of the Tree Frog Theloderma kwangsiensis.
RECORD: Rec_0027707 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans 08022821
25 μg/mL
MIC
PMID24004075 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24004075/
RECORD: Rec_0042929 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
20-26
Bio-Activity Profile
Antimicrobial Antifungal Antioxidant
B. dysenteriae
50 μg/mL
MIC
PaperA Novel Antimicrobial Peptide from Skin Secretions of the Tree Frog Theloderma kwangsiensis.
RECORD: Rec_0059242 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
100 μg/mL
Hemolysis
PMID24004075 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24004075/
RECORD: Rec_0123559 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiense [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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