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MYP_173870
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Basic Information
Antimicrobial peptide 2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
36 amino acids
C158H247N55O49S6
Standard
Sequence
CIGNGGRCNENVGPPYCCSGFCLRQPNQGYGVCRNR
Physicochemical Analysis
3893.38 Da
8.69
2.70
2.41
0.0750
-0.62
0.48
-0.14
27.62
37.78
0.0833
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1702.67
-24.75
63.0
58.0
122.0
268.0
6.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0124121 VERIFIED: YES
Provenance & Taxonomy
Garden four-o [Plant]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bonds
Bio-Activity Profile
Antimicrobial Antifungal
Bacillus megaterium
2 μg/mL
IC50
PaperIsolation and characterization of a novel class of plant antimicrobial peptides from Mirabilis jalapa L. seeds.
RECORD: Rec_0131962 VERIFIED: YES
Provenance & Taxonomy
Mirabilis jalapa [Plant]
Gurmarin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Bacillus megaterium
2 μg/mL
MIC
PMID1733929;7647302 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1733929/
RECORD: Rec_0134803 VERIFIED: YES
Provenance & Taxonomy
Mirabilis jalapa [Plant]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0137818 VERIFIED: YES
Provenance & Taxonomy
Mirabilis jalapa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
None
1-18, 8-22, 17-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Bacillus megaterium
2 μg/mL
MIC
PMID1733929;7647302 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1733929/
RECORD: Rec_0162043 VERIFIED: YES
Provenance & Taxonomy
Mirabilis jalapa [Plant]
Knottin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Anti-Gram-negative
Erwinia carotovora
500 μg/mL
IC50
PaperPubMed PMID 2387889 | PubMed PMID 27208129 PMID2387889;27208129;23878892;7208129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2387889/
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