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MYP_173788
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
31 amino acids
C136H223N35O41S6
Standard
Sequence
GSIPCGESCVFIPCISSVIGCACKSKVCYKN
Physicochemical Analysis
3196.83 Da
8.33
1.70
1.40
0.0548
0.70
0.43
0.24
32.47
81.61
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1198.57
-14.12
47.0
49.0
102.0
218.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0332898 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human gastric cancer BGC-823
1.75±0.05 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 25815330 PMID25815330 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
RECORD: Rec_0366681 VERIFIED: NO
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
PaperPlant Antimicrobial Oligopeptides with Anticancer Properties as a Source of Biologically Active Peptides—An In Silico Study PMID41009751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41009751/
RECORD: Rec_0367277 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Cancer cell lines: BGC-823
1.75±0.05 μM
IC50
PaperPubMed PMID: 21723349 PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0411123 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 32.3%, T 38.7%, C 29.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0424734 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human skin melanoma MM96L
4.91±0.04 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 25815330 PMID25815330 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
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