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MYP_173788
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
31 amino acids
C136H223N35O41S6
Standard
Sequence
GSIPCGESCVFIPCISSVIGCACKSKVCYKN
Physicochemical Analysis
3196.83 Da
8.33
1.70
1.40
0.0548
0.70
0.43
0.24
32.47
81.61
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1198.57
-14.12
47.0
49.0
102.0
218.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188914 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0217435 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Viola philippica
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
PMID21723349;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0253226 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Non-cancer cell line: HFF-1
3.19±0.01 μM
IC50
PaperPubMed PMID: 21723349 PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0278092 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
HeLa
15.5±0.06 μM
IC50
PaperPubMed PMID: 21723349 PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0329704 VERIFIED: YES
Provenance & Taxonomy
Melicytus dentatus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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