Peptide Database

Peptide NameResistin-like alpha

Function Ontology

Cardiovascular

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length88 amino acids

Chemical FormulaC408H652N114O126S12

DescriptionStandard

        DGTLDIIGKKKVKELLAHQDNYPSAVRKTLSCTNVKSMSKWASCPAGMTATGCSCGFACGSWEIQNENICNCLCLIVDWAYARCCQLS
    

Molecular Weight9555.01 Da

Isoelectric Point (pI)8.09

Net Charge (pH 7.0)1.75

Net Charge (pH 7.4) 1.33

Charge Density (pH 7.0) 0.0199

GRAVY Index-0.01

Hydrophobic Moment 0.51

Boman Index0.06

Instability Index44.31

Aliphatic Index 75.45

Aromaticity 0.0682

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 20105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3868.70

LogP -44.27

H-bond Donors 144.0

H-bond Acceptors 141.0

Rotatable Bonds 316.0

Heavy Atoms 660.0

Ring Count 12.0

Amide Bonds 95.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0254730 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyResistin-like

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide32-85; 44-84; 53-70; 55-72; 59-74

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular

Half-LifeMammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour

RECORD: Rec_0301767 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0303426 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyResistin/FIZZ

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone-like secreted