Peptide Database

Peptide NameTemporin A

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Immunology ▸ Immune cell migration ▸ Chemotactic peptide

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Wound healing/Regeneration ▸ Wound healing

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC68H116N16O15

DescriptionStandard

        FLPLIGRVLSGIL
    

Molecular Weight1397.75 Da

Isoelectric Point (pI)9.75

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0585

GRAVY Index1.81

Hydrophobic Moment 0.59

Boman Index0.59

Instability Index32.33

Aliphatic Index 202.31

Aromaticity 0.0769

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 485.86

LogP -0.58

H-bond Donors 17.0

H-bond Acceptors 16.0

Rotatable Bonds 44.0

Heavy Atoms 99.0

Ring Count 2.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0398217 VERIFIED: YES

Provenance & Taxonomy

OrganismRana temporaria [Animal]

FamilyTemporin

Tax ID8400

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Anticancer Cytotoxic

TargetU-937

Activity0.5 μg/mL

MethodCytotoxicity assay

RECORD: Rec_0407042 VERIFIED: YES

Provenance & Taxonomy

OrganismRana temporaria [Animal]

FamilyTemporin

Tax ID8407

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-FV3 Entry inhibition

TargetFrog Virus 3 (FV3)

Activity58 μM

Method% inhibition

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperInactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides. | Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L. | Virology. 2004 Jun 1;323(2):268-75. | DOI:10.1016/j.virol.2004.02.029 | PMID:15193922 PMID15193922 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15193922/

RECORD: Rec_0419652 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer

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