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MYP_173726
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Basic Information
Temporin A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
13 amino acids
C68H116N16O15
Standard
Sequence
FLPLIGRVLSGIL
Physicochemical Analysis
1397.75 Da
9.75
0.76
0.56
0.0585
1.81
0.59
0.59
32.33
202.31
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
485.86
-0.58
17.0
16.0
44.0
99.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000215 VERIFIED: NO
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0004160 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Human erythrocytes
14 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/11995990/ PMID11995990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11995990/
RECORD: Rec_0020327 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Human erythrocytes
225 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/11995990/ PMID11995990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11995990/
RECORD: Rec_0037144 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 30.8%, E 0.0%, T 38.5%, C 30.8% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Antiviral Antiparasitic Toxic Antimicrobial Antifungal Hemolytic Anti-Gram-positive Antileishmanial Anti-Gram-negative Chemotactic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0037792 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
8407
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer Antiparasitic Wound healing
Escherichia coli
6.2-100 μM
MIC
PaperTemporins, antimicrobial peptides from the European red frog Rana temporaria.
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