Peptide Database

Peptide NameProgonadoliberin-1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length69 amino acids

Chemical FormulaC341H543N99O108S

DescriptionStandard

        QHWSYGLRPGGKRNAENLIDSFQEIAKEADQLAEPQHFECTISQPRSPLRALKGALESLIEEETGQKKI
    

Molecular Weight7789.62 Da

Isoelectric Point (pI)5.62

Net Charge (pH 7.0)-2.05

Net Charge (pH 7.4) -2.40

Charge Density (pH 7.0) -0.0298

GRAVY Index-0.85

Hydrophobic Moment 0.70

Boman Index-0.14

Instability Index75.65

Aliphatic Index 76.52

Aromaticity 0.0580

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3374.67

LogP -35.26

H-bond Donors 114.0

H-bond Acceptors 109.0

Rotatable Bonds 266.0

Heavy Atoms 549.0

Ring Count 11.0

Amide Bonds 76.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0213711 VERIFIED: NO

Provenance & Taxonomy

OrganismTupaia belangeri [Animal]

FamilyGnRH

Tax ID37347

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Other ModsGly10 Amidation

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide

RECORD: Rec_0240317 VERIFIED: NO

Provenance & Taxonomy

OrganismTupaia belangeri [Animal]

FamilyProgonadoliberin

Tax ID37347

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods10:Glycine amide

Bio-Activity Profile

Function

Hormone Endocrine Reproductive regulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0342059 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/