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MYP_173414
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Basic Information
WN53
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C142H203N37O36S
Standard
Sequence
TFLVHREWFMDLNLPWSSAGSTVWR
Physicochemical Analysis
3036.42 Da
6.42
-0.51
-0.75
-0.0204
-0.08
0.50
0.14
22.78
74.00
0.2000
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1171.62
-7.50
43.0
38.0
91.0
216.0
10.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037460 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
LLCMK-2 monkey kidney epithelial cells
PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
RECORD: Rec_0102248 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-WNV Fusion inhibition
West Nile virus (WNV) | epithelial cells
10 μM
IC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses. | da Silva-Júnior EF, de Araújo-Júnior JX. | Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978. | DOI:10.1016/j.bmc.2019.07.038 | PMID:31351847 PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
RECORD: Rec_0169616 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
West Nile virus(WNV):inhibition of WNV infection in LLCKM-2 monkey kidney epithelial cells
IC50
PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
RECORD: Rec_0253507 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0375976 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
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