Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length63 amino acids

Chemical FormulaC296H490N84O89S3

DescriptionStandard

        CPQVCQIVVKSVHDELQPYLRTLPVTARIDARAGIDYSLVAPPTATAQSLDVDLKVRGCPGKA
    

Molecular Weight6745.76 Da

Isoelectric Point (pI)7.93

Net Charge (pH 7.0)0.82

Net Charge (pH 7.4) 0.51

Charge Density (pH 7.0) 0.0130

GRAVY Index0.06

Hydrophobic Moment 0.57

Boman Index0.04

Instability Index34.83

Aliphatic Index 103.65

Aromaticity 0.0317

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2747.35

LogP -27.92

H-bond Donors 96.0

H-bond Acceptors 94.0

Rotatable Bonds 214.0

Heavy Atoms 472.0

Ring Count 9.0

Amide Bonds 66.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0245778 VERIFIED: NO

Provenance & Taxonomy

OrganismStrix occidentalis caurina [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence