Peptide Database

Peptide NameSLAY-screened peptide P3458

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC104H166N34O27S3

DescriptionStandard

        PDFVTHCRVYRHCCKRSILS
    

Molecular Weight2420.84 Da

Isoelectric Point (pI)9.20

Net Charge (pH 7.0)3.10

Net Charge (pH 7.4) 2.90

Charge Density (pH 7.0) 0.1551

GRAVY Index-0.28

Hydrophobic Moment 0.61

Boman Index-0.21

Instability Index43.02

Aliphatic Index 68.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 989.53

LogP -9.89

H-bond Donors 41.0

H-bond Acceptors 35.0

Rotatable Bonds 77.0

Heavy Atoms 168.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0118841 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/