Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H146N24O26S3

DescriptionStandard

        TLLCDCPNGPWVWVPAFCQA
    

Molecular Weight2220.59 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.63

Net Charge (pH 7.4) -1.86

Charge Density (pH 7.0) -0.0815

GRAVY Index0.58

Hydrophobic Moment 0.24

Boman Index0.37

Instability Index26.80

Aliphatic Index 78.00

Aromaticity 0.1500

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 765.14

LogP -4.32

H-bond Donors 27.0

H-bond Acceptors 28.0

Rotatable Bonds 59.0

Heavy Atoms 155.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0307445 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 (RU570) | TZM-bl cells

Activity1.29 μM

MethodIC50

Half-LifeMammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h

PaperPeptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition. | Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H. | J Virol. 2011 Jul;85(14):7037-47. | DOI:10.1128/JVI.02366-10 | PMID:21543477 PMID21543477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21543477/

RECORD: Rec_0320305 VERIFIED: YES