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MYP_173274
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Basic Information
Cypemycin
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C98H162N24O30S2
Standard
Sequence
ATPATPTVAQFVIQGSTICLVC
Physicochemical Analysis
2220.61 Da
5.55
-0.22
-0.44
-0.0102
1.11
0.33
0.42
23.63
106.36
0.0455
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
844.17
-9.46
30.0
32.0
65.0
154.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0243224 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Antitumor Anti-Gram-positive
Alex
25 μg/mL
IC50
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
RECORD: Rec_0244978 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15235601 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15235601/
RECORD: Rec_0290863 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Antitumor Anti-Gram-positive
HCC-M
25 μg/mL
IC50
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
RECORD: Rec_0302729 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Cypemycin does not contain lanthionine bridges but exhibits some of the structural features of lantibiotics, notably 4 dehydrated threonines (dehydrobutyrines, Dhb) and a C-terminal S-[(Z)-2-aminovinyl]-d-cysteine. Cypemycin also possesses two l-allo-isoleucine residues and an N-terminal N,N-dimethylalanine, both unique amino acid modifications. Different from lantibiotics, Cys19 (not Ser) is dehydated and forms a ring structure with Cys22 (Claesen J and Bibb M 2010 PNAS 107:16297-302). Natural variant: Grisemycin, with three residues 5-7 deleted, has been found, but its antimicrobial activity against M. luteus was not detected even using concentrated supernatant (J Bacteriol. 2011 May;193(10):2510-6). APD update 9/21/2012; 4/2016; 7/2021 GW
Bio-Activity Profile
Antimicrobial
Micrococcus luteus
0.2 μg/mL
MIC
PaperA new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics
RECORD: Rec_0314642 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 18.2%, T 40.9%, C 40.9% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antibacterial Antimicrobial Anti-Gram-positive Antitumor
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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