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MYP_173274
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Basic Information
Cypemycin
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C98H162N24O30S2
Standard
Sequence
ATPATPTVAQFVIQGSTICLVC
Physicochemical Analysis
2220.61 Da
5.55
-0.22
-0.44
-0.0102
1.11
0.33
0.42
23.63
106.36
0.0455
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
844.17
-9.46
30.0
32.0
65.0
154.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075307 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
[Ref. 10.1016/S0040-4039(00)78407-3] Dimethylation on Ala1
Cyclization
①Thr2, Thr5, Thr7 and Thr17 converts to (E)-2,3-didehydrobutyrine. ②Ile13 and Ile18 converts to L-allo-isoleucine. ③Maturation involves the enzymatic conversion of Cys-19 into 2,3-didehydroalanine followed by formation of a thioether bond with Cys-22. The C-terminal meso-lanthionine then undergoes decarboxylation
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic Anticancer
leukemia cells in vitro
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
RECORD: Rec_0119004 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Micrococcus luteus
0.096 μM
MIC
PMID28452467 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28452467/
RECORD: Rec_0126576 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0155602 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Antitumor Anti-Gram-positive
P388 leukemia
1.3 μg/mL
IC50
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
RECORD: Rec_0168199 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
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