‹ ›
MYP_173274
← PREVIOUS NEXT → BACK
Basic Information
Cypemycin
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C98H162N24O30S2
Standard
Sequence
ATPATPTVAQFVIQGSTICLVC
Physicochemical Analysis
2220.61 Da
5.55
-0.22
-0.44
-0.0102
1.11
0.33
0.42
23.63
106.36
0.0455
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
844.17
-9.46
30.0
32.0
65.0
154.0
3.0
23.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0002003 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Antitumor Anti-Gram-positive
HCC-1
25 μg/mL
IC50
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
RECORD: Rec_0016207 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
[Ref. 10.1016/S0040-4039(00)78407-3] Dimethylation on Ala1
Cyclization
①Thr2, Thr5, Thr7 and Thr17 converts to (E)-2,3-didehydrobutyrine. ②Ile13 and Ile18 converts to L-allo-isoleucine. ③Maturation involves the enzymatic conversion of Cys-19 into 2,3-didehydroalanine followed by formation of a thioether bond with Cys-22. The C-terminal meso-lanthionine then undergoes decarboxylation
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus
0.2 μg/mL
MIC
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
RECORD: Rec_0025665 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Antitumor Anti-Gram-positive
HeLa S3
25 μg/mL
IC50
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
RECORD: Rec_0055783 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Antitumor Anti-Gram-positive
L929
25 μg/mL
IC50
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
RECORD: Rec_0064669 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. OH-4156 [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
[Ref. 10.1016/S0040-4039(00)78407-3] Dimethylation on Ala1
Cyclization
①Thr2, Thr5, Thr7 and Thr17 converts to (E)-2,3-didehydrobutyrine. ②Ile13 and Ile18 converts to L-allo-isoleucine. ③Maturation involves the enzymatic conversion of Cys-19 into 2,3-didehydroalanine followed by formation of a thioether bond with Cys-22. The C-terminal meso-lanthionine then undergoes decarboxylation
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic
PMID7802859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7802859/
1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 1 of 4