Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length144 amino acids

Chemical FormulaC687H1147N179O204S7

DescriptionStandard

        MITLQLGSGLLDVQVDVKAAAIEANGTQIPLFTLSVNSSFTGKMMIADGKLKGNVMLNNVTLTVEATEIGEFKTDALKSGIKSGMIVALGQLNAKLGKGIILPRMKHAQLVNTILKMQKGFVAIYSDVQILQTDRSSFLSTSYL
    

Molecular Weight15402.99 Da

Isoelectric Point (pI)9.44

Net Charge (pH 7.0)3.59

Net Charge (pH 7.4) 3.29

Charge Density (pH 7.0) 0.0249

GRAVY Index0.32

Hydrophobic Moment 0.56

Boman Index0.18

Instability Index16.53

Aliphatic Index 113.75

Aromaticity 0.0486

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6176.63

LogP -60.11

H-bond Donors 211.0

H-bond Acceptors 216.0

Rotatable Bonds 535.0

Heavy Atoms 1077.0

Ring Count 10.0

Amide Bonds 158.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0120905 VERIFIED: NO

Provenance & Taxonomy

OrganismPoeciliopsis prolifica [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria