Peptide Database

Peptide Namecompound 1 [PMID: 25241924]

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC72H106N16O18

DescriptionStandard

        VTLPLWATYTYR
    

Molecular Weight1483.71 Da

Isoelectric Point (pI)8.56

Net Charge (pH 7.0)0.73

Net Charge (pH 7.4) 0.52

Charge Density (pH 7.0) 0.0610

GRAVY Index0.16

Hydrophobic Moment 0.31

Boman Index0.22

Instability Index4.18

Aliphatic Index 97.50

Aromaticity 0.2500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 553.47

LogP -1.97

H-bond Donors 21.0

H-bond Acceptors 19.0

Rotatable Bonds 40.0

Heavy Atoms 106.0

Ring Count 5.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0353932 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsThe N-terminal valine residue is linked to a palmitate chemical group, and the C-terminal arginine residue has an amide group attached.

Bio-Activity Profile

Function

Receptor agonist Vasoactive Signaling peptide

Targetapelin receptor (Human)

Activity33.7 nM

MethodEC50