Peptide Database

Peptide NamePotassium channel blocker alpha-KTx 26.1

Function Ontology

Annotation / Sequence feature ▸ Nuclear export signal

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC168H266N54O47S6

DescriptionStandard

        NFKVEGACSKPCRKYCIDKGARNGKCINGRCHCYY
    

Molecular Weight3986.63 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)5.78

Net Charge (pH 7.4) 5.43

Charge Density (pH 7.0) 0.1653

GRAVY Index-0.77

Hydrophobic Moment 0.68

Boman Index-0.25

Instability Index2.59

Aliphatic Index 36.29

Aromaticity 0.1143

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1673.20

LogP -19.27

H-bond Donors 65.0

H-bond Acceptors 60.0

Rotatable Bonds 133.0

Heavy Atoms 275.0

Ring Count 6.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0115668 VERIFIED: YES

Provenance & Taxonomy

OrganismMesobuthus martensii [Animal]

FamilyPotassium channel inhibitor family

Tax ID34649; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide8-26; 12-31; 16-33

Bio-Activity Profile

Function

Toxin Venom Potassium channel inhibitor family Ion channel inhibitor Pathogenesis-associated Host defense