Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length145 amino acids

Chemical FormulaC707H1156N182O206S7

DescriptionStandard

        MMKLLVRTAKNPVVTFEPNNATVEASSTVTAYAIQPNATLSPLFVLNMETSVSARVFVSGMRLAGAVNLNKMDLTLGTSYVGDFQVRTLNSIFQTVLKLVVIPTLNVQLAKGYPLPTLGKMNLVNTQLQVLKDYVMVGTDVQFTG
    

Molecular Weight15726.29 Da

Isoelectric Point (pI)9.57

Net Charge (pH 7.0)3.50

Net Charge (pH 7.4) 3.26

Charge Density (pH 7.0) 0.0242

GRAVY Index0.36

Hydrophobic Moment 0.71

Boman Index0.19

Instability Index18.23

Aliphatic Index 108.07

Aromaticity 0.0690

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6225.09

LogP -60.72

H-bond Donors 211.0

H-bond Acceptors 217.0

Rotatable Bonds 516.0

Heavy Atoms 1102.0

Ring Count 17.0

Amide Bonds 162.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0225362 VERIFIED: NO

Provenance & Taxonomy

OrganismLiparis tanakae [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence