Peptide Database

Peptide NameKappa-stichotoxin-She3a (Kappa-SHTX-She3a) (Potassium channel toxin ShK)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC169H280N54O48S7

DescriptionStandard

        RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
    

Molecular Weight4060.82 Da

Isoelectric Point (pI)9.55

Net Charge (pH 7.0)6.78

Net Charge (pH 7.4) 6.43

Charge Density (pH 7.0) 0.1938

GRAVY Index-0.46

Hydrophobic Moment 0.41

Boman Index-0.26

Instability Index31.87

Aliphatic Index 36.29

Aromaticity 0.0857

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1686.75

LogP -21.29

H-bond Donors 69.0

H-bond Acceptors 63.0

Rotatable Bonds 136.0

Heavy Atoms 278.0

Ring Count 5.0

Amide Bonds 35.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0246577 VERIFIED: YES

Provenance & Taxonomy

OrganismStichodactyla helianthus [Animal]

FamilySea anemone type 1 potassium channel toxin; Type 1a subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetPseudomonas aeruginosa (Gram-negative)

RECORD: Rec_0272986 VERIFIED: YES