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MYP_172876
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Basic Information
Kappa-stichotoxin-She3a (Kappa-SHTX-She3a) (Potassium channel toxin ShK)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
35 amino acids
C169H280N54O48S7
Standard
Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
Physicochemical Analysis
4060.82 Da
9.55
6.78
6.43
0.1938
-0.46
0.41
-0.26
31.87
36.29
0.0857
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1686.75
-21.29
69.0
63.0
136.0
278.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028724 VERIFIED: YES
Provenance & Taxonomy
Stichodactyla helianthus [Animal]
Sea anemone type 1 potassium channel toxin; Type 1a subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic
Staphylococcus aureus (Gram-positive)
PMID7660365;8567178;8645244;10419508;15665253;22683676;28796463;21867724;29316700;8599755;9830012;10545177;19122005;23919482;26288216;28194851 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7660365/
RECORD: Rec_0028733 VERIFIED: NO
Provenance & Taxonomy
Stichodactyla helianthus [Animal]; Stoichactis helianthus [Animal]
Structure & Mods
linear disulfide-stabilized peptide [Linear]
canonical L-amino-acid peptide [L]
3-35, 12-28, 17-32
Bio-Activity Profile
Toxin
Kv1
RECORD: Rec_0029491 VERIFIED: YES
Provenance & Taxonomy
Stichodactyla helianthus [Animal]
sea anemone type 1 potassium channel toxin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-35; 12-28; 17-32
Bio-Activity Profile
Toxin Venom sea anemone type 1 potassium channel toxin family
PaperPDB 4LFQ structural record; X-ray; 1.06 A; chain A; residues 1-35
RECORD: Rec_0064229 VERIFIED: YES
Provenance & Taxonomy
Stichodactyla helianthus [Animal]
Sea anemone type 1 potassium channel toxin; Type 1a subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic
S. typhimurium
PMID7660365;8567178;8645244;10419508;15665253;22683676;28796463;21867724;29316700;8599755;9830012;10545177;19122005;23919482;26288216;28194851 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7660365/
RECORD: Rec_0163942 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 40.0%, E 0.0%, T 28.6%, C 31.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Cytotoxic
PaperIn silico approach for predicting toxicity of peptides and proteins PMID24058508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24058508/
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