Peptide Database

Peptide NameBMP-5

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length138 amino acids

Chemical FormulaC680H1049N199O204S11

DescriptionStandard

        AANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
    

Molecular Weight15628.53 Da

Isoelectric Point (pI)8.70

Net Charge (pH 7.0)4.34

Net Charge (pH 7.4) 3.66

Charge Density (pH 7.0) 0.0315

GRAVY Index-0.55

Hydrophobic Moment 0.59

Boman Index-0.08

Instability Index60.97

Aliphatic Index 63.62

Aromaticity 0.0942

Extinction Coeff. Reduced 19940.00

Extinction Coeff. Oxidized 20315.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6526.87

LogP -73.87

H-bond Donors 230.0

H-bond Acceptors 226.0

Rotatable Bonds 513.0

Heavy Atoms 1094.0

Ring Count 28.0

Amide Bonds 154.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0251759 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThe active peptide is a homodimer linked by a disulphide bond between cysteine residues at position 102 of each chain. Predicted N-linked glycososylation of asparagine residues at positions 11, 29 and 79. Predicted disulphide bond formation between cysteine residues at positions 37 and 103, 66 and 135, and 70 and 137

Bio-Activity Profile

Function

Receptor agonist Immunomodulatory Signaling peptide

TargetBone morphogenetic protein receptors (Human)