Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length511 amino acids

Chemical FormulaC2575H4087N691O712S18

DescriptionStandard

        MSPVDSFIALWSHLKALRSWQLWRMREDVARGLHDAPRWASLLVLVAVGTTVTAATNPGVMVRISQKGLDYASQQGTAALQKELKRIKIPDYSGRFKIKLLGKGRYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKARKHFIKTSGNFDLRVEGVSISADLKLGSNSTSGKPTVTCSSCSSHINSVHVRISKSRVGWLIRLFRKKIESTLRNKLNSQVCEKVTSSVSSKLQPYFQTLPVMTKIDAVAGINYGLVAPPTTTAETLDVQMKGEFYSQNHHSPPPFAPAVMEFPAAHDHMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKMFPNMKIQIHVSASAPPHLSVQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGVSTTASMEVGAKSDRLVGKLKVDRLILELKHSNIGPFPVELLQAIMNYVVPTFVLPRVNEKLQKGFPLPTPARVQLYNTVLQPHQNFLLFGADVVHK
    

Molecular Weight56694.37 Da

Isoelectric Point (pI)9.90

Net Charge (pH 7.0)26.71

Net Charge (pH 7.4) 25.62

Charge Density (pH 7.0) 0.0523

GRAVY Index-0.03

Hydrophobic Moment 0.82

Boman Index0.08

Instability Index37.90

Aliphatic Index 92.49

Aromaticity 0.0900

Extinction Coeff. Reduced 52370.00

Extinction Coeff. Oxidized 52495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0048420 VERIFIED: NO

Provenance & Taxonomy

OrganismCercocebus atys [Animal]

FamilyBPI

Tax ID9531

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence