Peptide Database

Peptide NameSLAY-screened peptide P3812

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC67H111N15O14S

DescriptionStandard

        LVIEPLMIWRL
    

Molecular Weight1382.76 Da

Isoelectric Point (pI)6.00

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0216

GRAVY Index1.45

Hydrophobic Moment 0.22

Boman Index0.48

Instability Index66.55

Aliphatic Index 203.64

Aromaticity 0.0909

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 460.52

LogP 2.24

H-bond Donors 16.0

H-bond Acceptors 15.0

Rotatable Bonds 43.0

Heavy Atoms 97.0

Ring Count 3.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412009 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/