Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length325 amino acids

Chemical FormulaC1657H2605N411O476S16

DescriptionStandard

        MMVKICCSLLLLSLLSVQLKANPGVKVRITQKALEYAKEVGLEILKKNMEKEQFPDLTGYERFGLGNVNYNISRIRVTAVEFPSVSISLIPRNGIKLVIKNASLTISMNWNMRTWMFKDSGRSTAYISKVFVTATFSTSLDSTGHTSLLLNSCRTTSGDTDIKLNGKSGFLHDFFIKYLKKPIHRSLATNGIVYPAGNHTDPPYVATPFTVPDQSDYMFYFSFSKYFFQTYIFSYYTEGAFNITIAEVAKYSIIPNPVMMKLMPTEIPLISLQQNSLTLEIEESMEVFAVLPDSTTQSLFTVNVVSTINKVAFNSGLNILVLSCC
    

Molecular Weight36412.92 Da

Isoelectric Point (pI)8.93

Net Charge (pH 7.0)5.82

Net Charge (pH 7.4) 5.24

Charge Density (pH 7.0) 0.0179

GRAVY Index0.13

Hydrophobic Moment 0.77

Boman Index0.14

Instability Index31.68

Aliphatic Index 95.63

Aromaticity 0.1108

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0223480 VERIFIED: NO

Provenance & Taxonomy

OrganismCallipepla squamata [Animal]

FamilyBPI

Tax ID9009

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence