Peptide Database

Peptide NameSLAY-screened peptide P4451

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC46H68N12O12

DescriptionStandard

        TTIFWTRG
    

Molecular Weight981.11 Da

Isoelectric Point (pI)9.41

Net Charge (pH 7.0)0.40

Net Charge (pH 7.4) 0.21

Charge Density (pH 7.0) 0.0498

GRAVY Index-0.07

Hydrophobic Moment 0.24

Boman Index0.15

Instability Index-20.65

Aliphatic Index 48.75

Aromaticity 0.2500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 405.40

LogP -3.16

H-bond Donors 16.0

H-bond Acceptors 13.0

Rotatable Bonds 28.0

Heavy Atoms 70.0

Ring Count 3.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0252205 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/