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MYP_172588
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Basic Information
AM-CATH36
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
36 amino acids
C194H337N57O38
Standard
Sequence
GLFKKLRRKIKKGFKKIFKRLPPIGVGVSIPLAGKR
Physicochemical Analysis
4076.11 Da
12.00
12.75
12.53
0.3542
-0.25
0.94
-0.14
29.96
105.56
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1557.46
-8.32
56.0
51.0
145.0
289.0
6.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0258942 VERIFIED: YES
Provenance & Taxonomy
Alligator mississippiensis [Animal]
cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 33592
21 μg/mL
MIC
PMID34121235;28089718 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34121235/
RECORD: Rec_0294968 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
sheep red cells
PMID28089718 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28089718/
RECORD: Rec_0315216 VERIFIED: YES
Provenance & Taxonomy
Alligator mississippiensis [Animal]
cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae ATCC BAA-1705
5.6 μg/mL
MIC
PMID34121235;28089718 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34121235/
RECORD: Rec_0326239 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii ATCC BAA-1794
5.2 μg/mL
MIC
PMID28089718 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28089718/
RECORD: Rec_0328090 VERIFIED: YES
Provenance & Taxonomy
American alligator [other]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Staphylococcus aureus ATCC 25923 or 33592
5.1 μM
MIC
PaperCathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae.
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