Peptide Database

Peptide NameUrocortin-2

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Stress-related neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length41 amino acids

Chemical FormulaC194H338N62O55S

DescriptionStandard

        IVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC
    

Molecular Weight4451.21 Da

Isoelectric Point (pI)10.15

Net Charge (pH 7.0)1.84

Net Charge (pH 7.4) 1.57

Charge Density (pH 7.0) 0.0450

GRAVY Index0.43

Hydrophobic Moment 0.59

Boman Index0.07

Instability Index33.39

Aliphatic Index 142.93

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1901.66

LogP -17.98

H-bond Donors 68.0

H-bond Acceptors 59.0

Rotatable Bonds 150.0

Heavy Atoms 312.0

Ring Count 2.0

Amide Bonds 44.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0005600 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyUrocortin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation Reproductive regulator Receptor modulation ACE inhibitory Feeding regulator

Half-LifeMammalian: 20 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0010863 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilySauvagine/corticotropin-releasing factor/urotensin I

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Stress-related neuropeptide

RECORD: Rec_0016774 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 70.7%, E 0.0%, T 14.6%, C 14.6% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-Cell Communication

RECORD: Rec_0214617 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0274994 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Familysauvagine/corticotropin-releasing factor/urotensin I family

Tax ID9606; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone sauvagine corticotropin-releasing factor urotensin I family