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MYP_172565
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ BChE Inhibitory
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid agonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuroactive peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
5 amino acids
C30H37N5O7
Standard
Sequence
YPFPG
Physicochemical Analysis
579.64 Da
5.52
-0.24
-0.45
-0.0482
-0.42
0.09
0.43
109.72
0.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
182.37
0.17
5.0
7.0
11.0
42.0
4.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0166767 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Casomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuroactive BChE Inhibitory
238.5
PaperJi D., Ma J., Dai J., Xu M., Harris, P. W. R., Brimble M. A., Agyei D.. Anticholinesterase inhibition, drug-likeness assessment, and molecular docking evaluation of milk protein-derived opioid peptides for the control of Alzheimer¡¯s disease. Dairy, 3, 422-437, 2022.
RECORD: Rec_0173952 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Casomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Acetylcholinesterase inhibitory
7151.0
PaperJi D., Ma J., Dai J., Xu M., Harris, P. W. R., Brimble M. A., Agyei D.. Anticholinesterase inhibition, drug-likeness assessment, and molecular docking evaluation of milk protein-derived opioid peptides for the control of Alzheimer¡¯s disease. Dairy, 3, 422-437, 2022.
RECORD: Rec_0183510 VERIFIED: YES
Provenance & Taxonomy
Bovine milk [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
AZ-97 (Inhibition at 9-11 g/l)
PaperPubMed PMID: 23533710 PMID23533710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23533710/
RECORD: Rec_0184890 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cognition-enhancing Neurotrophic
Neuro-2a mouse neuroblastoma cells
PaperNeurite Outgrowth-stimulating Activities of β-Casomorphins in Neuro-2a Mouse Neuroblastoma Cells | Sakaguchi, M. et al. | DOI: 10.1271/bbb.67.2541 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0269241 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cognition-enhancing Neurotrophic Opioid antagonist
Mice
PaperEffects of systemic administration of β-casomorphin-5 on learning and memory in mice | Sakaguchi, M. et al. | DOI: 10.1016/j.ejphar.2005.11.014 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
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